Reinsurance Group of America has agreed a 15-year lease with AXA Investment Managers to take up the 45th floor of 22 Bishopsgate, EC2.
The US life and health reinsurance company has taken up 27,000 sq ft and is due to move into the 1.4m sq ft building in the middle of next year.
The 62-storey skyscraper, currently under construction, is due to be handed over for fit-out in late 2019.
CBRE and JLL acted for 22 Bishopsgate, while Carter Jonas acted for Reinsurance Group of America.
Simon Wainwright, managing director, UK and Ireland at Reinsurance Group, said: “RGA’s UK